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Oral mucosal melanin hyperpigmentation associated with syndromes and systemic diseases Oral mucosal melanin hyperpigmentation is often observed in the systemic conditions such as Peutz-Jegher syndrome, McCune-Albright syndrome, Laugier-Hunziker syndrome, Addison disease, and neurofibromatosis

Oral mucosal melanoma: epidemiology and pathobiology

Immune Modulation Exhibits anti-inflammatory properties and potential use in fungal infections resistant to current antifungals (4)

Indeed, it has been suggested that certain cytokines that are upregulated during HIV infection have the capacity to induce the production of -MSH by oral melanocytes and keratinocytes and to mediate the upregulation of expression of MC1R by melanocytes, resulting in increased melanin production